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Phentermine is a medicine given to assist individuals with weight loss. It is an amine anorectic agent, which was initially introduced in the year 1959, as part of anti-obesity combination medicine. It is chemically associated to amphetamine and is commonly known as atypical amphetamine. It has been approved by the U.S. Food and Drug Administration (FDA) for short term management and control of excess weight. This initial combination drug, formed by dexfenfluramine and fenfluramine was discontinued after many reports of abnormal or unusual valves in about 30 percent of the customers. Buy Phentermine Online Overnight Delivery and take drug as prescribed by the GP.
Mechanism of Action
The medication acts identically to amphetamines in reducing the appetite, elevating blood pressure and inducing central nervous system. It is consumed as an extended release capsule or a tablet, with dose and timing determined according to the form. Usually, extended release capsule is consumed once daily in the morning, whereas the tablets are consumed half an hour before eating food, three times in a day.
After a dose, the medicine gets absorbed in body through gastrointestinal tract and achieves peak concentration in blood in 3-4 hours. Phentermine has half-life of around 24 hours, which is the period it takes for almost half of dose to get metabolized through liver or passed unchanged in urine. Normally, it takes 5 to 6 half-lives for medications to be nearly completely eliminated from the body.Buy Phentermine Online Overnight and get it at low rates.
The medicine is indicated, in combination or alone with topiramate, as short term auxiliary, not exceed a few weeks, in regime of weight reduction established on caloric restriction, behavioral modifications and exercise in management of exogenic obesity for people with initial body mass index higher than 27 kg/m2 or higher than 30 kg/m2 in presence of risk factors like hyperlipidemia, diabetes, or controller hypertension.
Exogenous obesity is believed when overweight is actually caused by eating more food than an individual activity level warrants.
It has been reported that the primary mechanism of phentermine is appetite suppression, perhaps due to increase in leptin; however it is thought that other mechanisms must be involved. Some medical reports have pointed that weight loss effect is primarily due to an augmentation in resting energy usage.
In clinical examinations where phentermine was utilized as a combination therapy or monotherapy, this medicine has demonstrated a mean weight loss of 3.5kg when equated with placebo in 3-24 weeks. Individuals treated with this medication also exhibited increased weight maintenance even after discontinuation of treatment. Though, this drug is derivative of amphetamines, it does not produce effects of amphetamine like QTc prolongation, tachyphylaxis, increased blood pressure or central nervous system stimulus. Buy Phentermine Online Cheap and take drug on time.